Effects of a single bout of aerobic exercise on oral glucose tolerance

Glycemic control  play an important  role in the management of type 2 diabetes (T2D), with postprandial glucose proposed as a better predictor of diabetes-related complications than fasting blood glucose or HbA1c. Therefore, studying postprandial blood glucose fluctuations has high physiological and clinical sinificance.

Aerobic exercise is prescribed clinically to prevent and treat T2D because it improves glycemic control and insulin sensitivity in obese and hyperglycemic individuals. Aerobic  exercise training is commonly accompanied by improvements in aerobic fitness and weight loss which independently influence glucose metabolism .

A single bout of aerobic exercise, that does not alter  body composition  or fitness of body, is sufficient to increase insulin sensitivity both in healthy , prediabetic and T2D persons. In healthy individuals, postprandial glucose tolerance has been shown to be unchanged, increased or decreased in the hours after a single bout of aerobic exercise.

In  prediabetic and T2D persons postprandial glucose tolerance after a single bout of exercise has been found to be improved in some studies while unchanged in others but a reduction of oral glucose tolerance immediately following exercise has never been found. Thus  it is found that the immediate effect of a single bout of exercise on postprandial plasma glucose levels differ between healthy and diabetic sub populations suggesting that it may be dependent on the subject’s underlying glycemic condition. Effect of single bout of exercise on plasma glucose kinetics following oral glucose ingestion would be influenced by the subject’s underlying level of oral glucose toleranc.

It is found that  the postprandial blood  glucose concentration following an oral glucose load was increased immediately following a single bout of aerobic exercise in subjects with NGT, this effect on glucose tolerance following exercise was not observed in persons with abnormal glycemic control (IGT and T2D).  The immediate effect of a single bout of aerobic exercise on oral glucose tolerance differs between healthy and diabetic subgroups, implying an impact of the underlying level of glycemic control. The exercise-induced increase in postprandial glucose response found in normal healthy persons .

Several factors may explain the lack of increase in postprandial oral glucose level found in IGT and T2D persons . 

Author: Dr.Ajay Kumar Singh

Dr. Ajay Kumar Singh was born on 2 Dec,1981 in Allahabad. He is an alumnus of GSVM Medical College Kanpur and MLN Medical College Allahabad. He worked for 8 years in the Uttar Pradesh Provincial services as Medical Officer. He offered his services at various place like Community Health Centre, Police Hospital, and Jail Hospital. He is a social thinker and writer. He is always ready to deliver his services to the needy person and patient. He works with the motto of making the healthy and happy society.

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